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CARD14-nEDD

Previously: Pityriasis rubra pilaris type V

nEDD Gene: CARD14 AD, AR (rare)

Onset: Infancy

Pathway: Miscellaneous

Category Paper: nEDD Paper

CARD14-nEDD: generalized scaling and erythema on the arm and the trunk.

Key Clinical Clues

Prominent facial involvement, pink-red coalescing plaques, localized or generalized scaling/erythema. Can have ectropion when severe.

Additional Cutaneous Features

Pink-red coalescing plaques with areas of sparing. Some individuals have pustules within plaques.

Additional Extracutaneous Features

Some individuals have joint pain.

Treatment

Ustekinumab and Th17 inhibitors work well (Takeichi, 2017; Craiglow, 2018).

References

Takeichi T, Sugiura K, Nomura T et al. Pityriasis rubra pilaris type V as an autoinflammatory disease by CARD14 mutations. JAMA Dermatol 2017; 153:66-70. || Craiglow BG, Boyden LM, Hu R et al. CARD14-associated papulosquamous eruption: a spectrum including features of psoriasis and pityriasis rubra pilaris. J Am Acad Dermatol 2018; 79:487-94.

Summarised from published literature for general information. This is not medical advice, and entries are still being verified. Read the full disclaimer

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The database is still being verified and entries may be incomplete. Do not rely on it without independent professional judgement.

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