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FLG-pEDD

Previously: Diffuse PPK associated with FLG variants

pEDD Gene: FLG AD

Onset: Childhood/adult

Pathway: Structural Proteins

Category Paper: pEDD Paper

FLG-pEDD: diffuse plantar keratoderma with xerosis, fissuring and erythema.

Key Clinical Clues

Diffuse nonpainful PPK, hyperlinearity, erythema, xerosis cutis.

References

Clabbers JMK, Bolling MC, Burms C et al. Palmoplantar keratoderma as a clinical feature of pathogenic variants in the filaggrin gene. J Eur Acad Dermatol Venereol 2023; 37:e486-90. | Liu C, Han C, Liang J et al. Variants in the gene encoding filaggrin cause autosomal-dominant symmetrical acral keratoderma. J Invest Dermatol 2023; 143:1313-17.

Summarised from published literature for general information. This is not medical advice, and entries are still being verified. Read the full disclaimer