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FLG2-nEDD

Previously: Peeling skin syndrome

nEDD Gene: FLG2 AR

Onset: Infancy

Pathway: Structural proteins

Category Paper: nEDD Paper

FLG2-nEDD: diffuse superficial skin peeling and erythema on the upper back and the shoulders.

Key Clinical Clues

Superficial skin peeling without erythema, mainly involving the limbs, sparing the face and palmoplantar skin.

References

Mohamad J, Sarig O, Godsel LM et al. Filaggrin 2 deficiency results in abnormal cell-cell adhesion in the cornified cell layers and causes peeling skin syndrome type A. J Invest Dermatol 2018; 138:1736-43.

Summarised from published literature for general information. This is not medical advice, and entries are still being verified. Read the full disclaimer