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KRT1-nEDD-annular

Previously: Annular epidermolytic ichthyosis

nEDD Gene: KRT1 AD

Onset: Childhood

Pathway: Structural proteins

Category Paper: nEDD Paper

KRT1-nEDD-annular: annular superficial erythematous and scaly lesions on the lower abdomen, typically transient.

Key Clinical Clues

A cyclic history of annular erythematous plaques with peripheral scale.

Additional Cutaneous Features

Histopathology: Granular degeneration, perinuclear vacuoles, sometimes epidermolysis.

Treatment

Small molecules, siRNA, repurposed drugs.

References

Zaki TD, Yoo K-Y, Kassardjian M, Choate KA. A p.4781>T KRT1 mutation in a case of annular epidermolytic ichthyosis. Pediatr Dermatol 2018; 35:e414-15.

Summarised from published literature for general information. This is not medical advice, and entries are still being verified. Read the full disclaimer