KRT10-nEDD-annular

Previously: Annular epidermolytic ichthyosis

nEDD Gene: KRT10 AD

Onset: Childhood

Pathway: Structural proteins

Category Paper: nEDD Paper

KRT10-nEDD-annular: annular scaly plaque on the inner left ankle. These lesions show superficial epidermolysis and are often transient.

Key Clinical Clues

A cyclic history of annular erythematous plaques with peripheral scale.

Additional Cutaneous Features

Histopathology: Granular degeneration, perinuclear vacuoles, sometimes epidermolysis.

Treatment

Small molecules, siRNA, repurposed drugs.

References

Suga Y, Duncan KO, Heald PW, Roop DR. A novel helix termination mutation in keratin 10 in annular epidermolytic ichthyosis, a variant of bullous congenital ichthyosiform erythroderma. J Invest Dermatol 1998; 111:1220-3.

Summarised from published literature for general information. This is not medical advice, and entries are still being verified. Read the full disclaimer