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KRT9-pEDD

Previously: Epidermolytic PPK

pEDD Gene: KRT9 AD

Onset: Infancy

Pathway: Structural Proteins

Category Paper: pEDD Paper

KRT9-pEDD: typical diffuse plantar keratoderma with fissuring.

Key Clinical Clues

Diffuse PPK with fissuring.

Additional Cutaneous Features

Histopathology: Epidermolytic hyperkeratosis/granular degeneration.

Treatment

siRNA (Sprecher, 2025), Botulinum toxin (Koren, 2020).

References

Reis A, Hennies HC, Langbein L et al. Keratin 9 gene mutations in epidermolytic palmoplantar keratoderma (EPPK). Nat Genet 1994; 6:174-9.

Summarised from published literature for general information. This is not medical advice, and entries are still being verified. Read the full disclaimer

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